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1.CRISPR tech selectively shreds cancer cells, including "undruggable" cancers (innovativegenomics.org)
499 points by gmays 5 hours ago | hide | 133 comments
2.I Am Not a Reverse Centaur (miguelgrinberg.com)
178 points by ibobev 3 hours ago | hide | 127 comments
3.Malware developers added nuclear and biological weapons text to to their spyware (twitter.com/jsrailton)
189 points by marc__1 5 hours ago | hide | 124 comments
4.How to setup a local coding agent on macOS (ikyle.me)
136 points by kkm 3 hours ago | hide | 45 comments
5.Pirates, a naval warfare game inspired by Sid Meier's Pirates (piwodlaiwo.github.io)
120 points by iweczek 3 hours ago | hide | 45 comments
6.Swift at Apple: Migrating the TrueType Hinting Interpreter (swift.org)
12 points by DASD 1 hour ago | hide | 3 comments
7.Launch HN: BitBoard (YC P25) – Analytics Workspace for Agents (bitboard.work)
26 points by arcb 4 hours ago | hide | 9 comments
8."Don't You Just Upload It to ChatGPT?" (correresmidestino.com)
171 points by speckx 3 hours ago | hide | 143 comments
9.Slightly reducing the sloppiness of AI generated front end (envs.net)
137 points by FergusArgyll 6 hours ago | hide | 97 comments
10.Where Did Earth Get Its Oceans? Maybe It Made Them Itself (quantamagazine.org)
85 points by ibobev 5 hours ago | hide | 50 comments
11.A PDF that changes based on how its read (sgaud.com)
94 points by SarthakGaud 4 hours ago | hide | 53 comments
12.Introduction to UEFI HTTP(s) Boot with QEMU/OVMF (yadutaf.fr)
55 points by jtlebigot 6 hours ago | hide | 14 comments
13.Cosmodial Sky Atlas (killedbyapixel.github.io)
19 points by memalign 2 hours ago | hide | 1 comment
14.A dumpster arrived behind my university's library (yalereview.org)
140 points by mooreds 6 hours ago | hide | 117 comments
15.There Is Life Before Main in Rust (grack.com)
51 points by mmastrac 4 hours ago | hide | 13 comments
16.Maxproof (arxiv.org)
120 points by ilreb 8 hours ago | hide | 10 comments
17.Law Enforcement's "Warrior" Problem (2015) (harvardlawreview.org)
70 points by bookofjoe 3 hours ago | hide | 52 comments
18.If you are asking for human attention, demonstrate human effort (tombedor.dev)
1425 points by jjfoooo4 21 hours ago | hide | 446 comments
19.Show HN: StackScope – I crawled over 40k indie launches to see what they ship (stackscope.dev)
35 points by datafreak_ 5 hours ago | hide | 10 comments
20.A Call to Action: Stop the FCC's KYC Regime (lopp.net)
290 points by FergusArgyll 6 hours ago | hide | 189 comments
21.Hazel (YC W24) Is Hiring a Full Stack Engineer (ycombinator.com)
7 hours ago | hide
22.WASI 0.3 (bytecodealliance.org)
207 points by mavdol04 7 hours ago | hide | 82 comments
23.Looking Forward to Postgres 19: It's About Time (pgedge.com)
103 points by xngbuilds 4 hours ago | hide | 31 comments
24.Encrypted Spaces An architecture for collaborative applications (encryptedspaces.org)
52 points by _____k 8 hours ago | hide | 5 comments
25.You can power on a Mac remotely (jeffgeerling.com)
22 points by speckx 5 hours ago | hide | 10 comments
26.A jacket that harvests drinking water from the air (utexas.edu)
153 points by ilreb 21 hours ago | hide | 95 comments
27.Kimi K2.7-Code: open-source coding model with better token efficiency (huggingface.co)
382 points by nekofneko 10 hours ago | hide | 199 comments
28.EV demand up 50% in France and Germany since Iran war (reuters.com)
28 points by a_paddy 2 hours ago | hide | discuss
29.New privacy frontier: Europe eyes crackdown on smart glasses (politico.com)
74 points by 1vuio0pswjnm7 4 hours ago | hide | 55 comments
30.Nobody ever gets credit for fixing problems that never happened (2001) [pdf] (web.mit.edu)
705 points by sam_bristow 20 hours ago | hide | 239 comments

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